Mechanism of hERG channel block by the psychoactive indole alkaloid ibogaine.
The Journal of pharmacology and experimental therapeutics February 1, 2014 Patrick Thurner, Anna Stary-Weinzinger, Hend Gafar et al. 41 citations
Ibogaine is a psychoactive indole alkaloid. Its use as an antiaddictive agent has been accompanied by QT prolongation and cardiac arrhythmias, which are most likely caused by human ether a go-go-related gene (hERG) potassium channel inhibition. Therefore, we studied in detail the interaction of ibogaine with hERG channels heterologously expressed in mammalian kidney tsA-201 cells. Currents...