Mechanism of hERG channel block by the psychoactive indole alkaloid ibogaine.
Journal of Pharmacology and Experimental Therapeutics February 1, 2014 Patrick Thurner, Anna Stary-Weinzinger, Hend Gafar et al. 41 citations
Ibogaine is a psychoactive indole alkaloid. Its use as an antiaddictive agent has been accompanied by QT prolongation and cardiac arrhythmias, which are most likely caused by human ether a go-go-related gene (hERG) potassium channel inhibition. Therefore, we studied in detail the interaction of ibogaine with hERG channels heterologously expressed in mammalian kidney tsA-201 cells. Currents...
DOI: 10.1124/jpet.113.209643 (opens in new tab)
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Ibogaine
Cardiotoxicity
Herg channel mechanism