Synthesis and structure-activity relationships of N-benzyl phenethylamines as 5-HT2A/2C agonists.
ACS Chemical Neuroscience March 19, 2014 Martin Hansen, Karina Phonekeo, James S Paine et al. 125 citations
N-Benzyl substitution of 5-HT2A receptor agonists of the phenethylamine structural class of psychedelics (such as 4-bromo-2,5-dimethoxyphenethylamine, often referred to as 2C-B) confer a significant increase in binding affinity as well as functional activity of the receptor. We have prepared a series of 48 compounds with structural variations in both the phenethylamine and N-benzyl part of the...