Tolerance and cross-tolerance to head twitch behavior elicited by phenethylamine- and tryptamine-derived hallucinogens in mice.
Journal of Pharmacology and Experimental Therapeutics December 1, 2014 Douglas A Smith, Jessica M Bailey, Diarria Williams et al. 31 citations
The serotonin 5-hydroxytryptamine 2A (5-HT2A) receptor is a potential therapeutic target to a host of neuropsychiatric conditions, but agonist actions at this site are linked to abuse-related hallucinogenic effects that may limit therapeutic efficacy of chronic drug administration. Tolerance to some effects of hallucinogens has been observed in humans and laboratory animals, but the...
DOI: 10.1124/jpet.114.219337 (opens in new tab)
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Drug tolerance
Drug adaptation
Pharmacological tolerance
Reduced drug effectiveness
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