Klaus Schicker

The mechanistic basis for noncompetitive ibogaine inhibition of serotonin and dopamine transporters.

Journal of Biological Chemistry May 25, 2012 Simon Bulling, Klaus Schicker, Yuan-Wei Zhang et al. 124 citations

Ibogaine, a hallucinogenic alkaloid proposed as a treatment for opiate withdrawal, has been shown to inhibit serotonin transporter (SERT) noncompetitively, in contrast to all other known inhibitors, which are competitive with substrate. Ibogaine binding to SERT increases accessibility in the permeation pathway connecting the substrate-binding site with the cytoplasm. Because of the structural...