Functional neurotoxicity evaluation of noribogaine using video-EEG in cynomolgus monkeys.
Journal of pharmacological and toxicological methods 2016 Simon Authier, Michael V Accardi, Dominique Paquette et al. 10 citations
Continuous video-electroencephalographic (EEG) monitoring remains the gold standard for seizure liability assessments in preclinical drug safety assessments. EEG monitored by telemetry was used to assess the behavioral and EEG effects of noribogaine hydrochloride (noribogaine) in cynomolgus monkeys. Noribogaine is an iboga alkaloid being studied for the treatment of opioid dependence. Six...