Remco Hs Westerink

2 papers in the library · 64 citations · publishing 2018-2019

Papers

Sort Most recent Most cited

Changes in neuronal activity in rat primary cortical cultures induced by illicit drugs and new psychoactive substances (NPS) following prolonged exposure and washout to mimic human exposure scenarios.

Neurotoxicology September 1, 2019 Anne Zwartsen, Laura Hondebrink, Remco Hs Westerink 22 citations

The use of new psychoactive substances (NPS) is increasing despite associated health risks and limited pharmacological and toxicological knowledge. Information is available mainly for acute effects on specific targets like monoamine transporters and receptors. Recently, we have shown the ability of several NPS and illicit drugs to modulate neuronal activity during acute exposure. While these...

DOI: 10.1016/j.neuro.2019.05.004 Full text Designer drugs Drugs of abuse Hallucinogens Stimulants +8

Neurotoxicity screening of new psychoactive substances (NPS): Effects on neuronal activity in rat cortical cultures using microelectrode arrays (MEA).

Neurotoxicology May 1, 2018 Anne Zwartsen, Laura Hondebrink, Remco Hs Westerink 42 citations

While the prevalence and the use of new psychoactive substances (NPS) is steadily increasing, data on pharmacological, toxicological and clinical effects is limited. Considering the large number of NPS available, there is a clear need for efficient in vitro screening techniques that capture multiple mechanisms of action. Neuronal cultures grown on multi-well microelectrode arrays (mwMEAs) have...

DOI: 10.1016/j.neuro.2018.03.007 Full text Drugs of abuse Hallucinogens Neurotoxicity screening Stimulants +8