Andras Domokos

Efficient and modular synthesis of ibogaine and related alkaloids.

Nature Chemistry March 1, 2025 Rishab N Iyer, David Favela, Andras Domokos et al. 22 citations

Anecdotal reports and preliminary clinical trials suggest that the psychoactive alkaloid ibogaine and its active metabolite noribogaine have powerful anti-addictive properties, producing long-lasting therapeutic effects across a range of substance use disorders and co-occurring neuropsychiatric diseases such as depression and post-traumatic stress disorder. Here we report a gram-scale,...