Glutamatergic mechanisms in early salience processing.
Frontiers in Pharmacology 2025 Denise Elfriede Liesa Lockhofen, Nils Hübner, Ranjan Debnath et al. 2 citations
Patients with schizophrenia frequently experience inadequate attribution of motivational salience, possibly related to impaired attentional processing and dysfunctional reward learning. According to the "glutamate hypothesis of schizophrenia", glutamatergic dysregulations can contribute to the emergence of psychotic symptoms and cognitive deficits in patients with schizophrenia. Blocking the...