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Amy Avakian

2 papers in the library · 1 citation · publishing 2025

Papers

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Disintegration of Default Mode: Functional MRI Insights Into N,N-Dimethyltryptamine (DMT), Consciousness, and Subcortical Connectivity.

Cureus July 1, 2025 Amy Avakian

N,N-Dimethyltryptamine (DMT), a potent endogenous psychedelic, evokes rapid and immersive shifts in consciousness that challenge conventional neurocognitive models. Functional magnetic resonance imaging (fMRI) and electroencephalography (EEG)-fMRI studies suggest that these altered states are not chaotic but patterned, marked by a disruption of the default mode network (DMN), an increase in...

Exploring the Neuroprotective and Neuropsychiatric Symptom Management Potential of Ketamine in Alzheimer's Disease.

Cureus June 1, 2025 Amy Avakian, Zachary I Merhavy 1 citation

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline, synaptic dysfunction, and neuroinflammation. Despite extensive research, current therapeutic options offer limited symptomatic relief without altering disease progression. Ketamine, an N-methyl-D-aspartate receptor (NMDAR) antagonist traditionally used as an anesthetic, has garnered...