LSD's rapid antidepressant effects are modulated by 5-HT2B receptors.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie July 16, 2025 Amel Bouloufa, Sarah Delcourte, Renaud Rovera et al. 12 citations
Recent clinical trials show that serotonergic psychedelics, including the prototypical hallucinogen lysergic acid diethylamide (LSD), possess a great promise for treating affective disorders. Interestingly, LSD displays strong functional activity on 5-HT2B receptors and a modulatory role of the latter receptors in anxious and depressive-like behaviors has been reported. Using behavioral and in...