The polypharmacology of psychedelics reveals multiple targets for potential therapeutics.
Neuron July 15, 2025 Manish K. Jain, Ryan H. Gumpper, Samuel T. Slocum et al. 42 citations
The classical psychedelics (+)-lysergic acid diethylamide (LSD), psilocybin, and mescaline exert their psychedelic effects via activation of the 5-HT2A serotonin receptor (5-HT2AR). Recent clinical studies have suggested that classical psychedelics may additionally have therapeutic potential for many neuropsychiatric conditions including depression, anxiety, migraine and cluster headaches, drug...