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Nik Ruzyanei Nik Jaafar

2 papers in the library · 5 citations · publishing 2022-2025

Papers

MBSR effects on positive psychological traits and experiential avoidance in head and neck cancer: a randomized controlled trial.

European Journal of Psychotraumatology December 1, 2025 Zheng Zhang, Qingqin Zhang, Ping Lu et al. 3 citations

In a randomized controlled trial of 80 head and neck cancer patients, a six-week mindfulness-based stress reduction (MBSR) program, compared with treatment as usual, significantly increased optimism from the start to the end of the program and from the end of the program to a later follow-up, with medium effect sizes. Hope did not increase during the program but did increase significantly at the follow-up. The program did not sustain changes in posttraumatic growth or experiential avoidance beyond the initial period. Experiential avoidance partially explained the link between MBSR and posttraumatic growth, while hope and optimism did not. The authors suggest MBSR can be part of treatment for these patients.

Case report: Effectiveness of brexpiprazole and esketamine/ketamine combination: A novel therapeutic strategy in five cases of treatment-resistant depression

Frontiers in Psychiatry July 22, 2022 Lai Fong Chan, Luke Sy-Cherng Woon, Nuur Asyikin Mohd Shukor et al. 2 citations

For patients with treatment-resistant depression who do not achieve functional recovery after multiple pharmacotherapies, combining brexpiprazole with esketamine or ketamine may offer a more rapid and effective augmentation strategy. This case series describes five complex cases of unipolar and bipolar treatment-resistant depression where conventional treatments failed to manage high-risk suicidal behavior or restore function. The authors discuss potential synergistic mechanisms of this novel combination, patient and clinical factors affecting response, challenges encountered, and implications for future practice and research.