Dose-dependent relationship between intra-operative ketamine administration and postoperative delirium: a retrospective cohort study.
Anaesthesia July 6, 2025 Lars Kaiser, Béla-Simon Paschold, Luca J Wachtendorf et al. 12 citations
Ketamine is used frequently as an adjunct for general anaesthesia, exerting analgesic and opioid-sparing properties at lower doses and psychotomimetic effects at higher doses. All dose ranges may have effects on the incidence of postoperative delirium, but clinical trials have been equivocal. We hypothesised that intra-operative low-dose ketamine is associated with a lower risk of postoperative...