Esketamine disinhibits brain networks in depression: Evidence from oscillatory and aperiodic activity.
Progress in Neuro-Psychopharmacology and Biological Psychiatry July 5, 2025 Verina Guirguis, Sanvi Korsapathy, Francesca Pupillo et al. 6 citations
Nasal Esketamine is a rapid-acting intervention for depression, hypothesized to exert its effects through cortical disinhibition. However, the spatio-temporal dynamics of brain network activity and their relationship to the subjective drug experience following Esketamine administration remain elusive. This observational study aims to delineate brain network-level effects of Esketamine by...
DOI: 10.1016/j.pnpbp.2025.111438 (opens in new tab)
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Major depressive disorder
Aperiodic exponent
Brain oscillations
Esketamine treatment
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