Nature
June 1, 2026
Kalman A Katlowitz, Eric R Cole, Elizabeth A Mickiewicz et al.
Consciousness is a fundamental component of cognition1, but the degree to which higher-order pattern recognition relies on it remains disputed2,3. Here we demonstrate the persistence of oddball discrimination, semantic processing and online prediction in individuals under general-anaesthesia-induced loss of consciousness4,5. Using high-density Neuropixels microelectrodes6 to record both...
bioRxiv : the preprint server for biology
April 9, 2025
Kalman A Katlowitz, Shraddha Shah, Melissa C Franch et al.
11 citations
preprint
Consciousness is a fundamental component of cognition, 1 but the degree to which higher-order perception relies on it remains disputed. 2,3 Here we demonstrate the persistence of learning, semantic processing, and online prediction in individuals under general anesthesia-induced loss of consciousness. 4,5 Using high-density Neuropixels microelectrodes 6 to record neural activity in the human...
Nature Communications
March 29, 2023
Fangyun Tian, Laura D. Lewis, David W. Zhou et al.
63 citations
The neural mechanisms underpinning ketamine’s dissociative and antidepressant effects remain poorly understood. Here, the authors analyzed ketamine-induced brain dynamics with intracranial recordings in humans and found that ketamine engages different brain areas in distinct frequency-dependent patterns that may relate to its dissociative and antidepressant effects. Ketamine produces...
bioRxiv Preprint Server
May 2, 2022
Fangyun Tian, Laura D. Lewis, David W. Zhou et al.
preprint
Subanesthetic doses of ketamine produce rapid and sustained anti-depressant effects in patients with treatment-resistant depression. Unfortunately, the usefulness of ketamine as a treatment is limited by its potential for abuse because of psychotropic side effects such as dissociation. Understanding the brain dynamics and the neural circuits involved in ketamine’s effects could lend insight...