Gwynne L. Davis

Ketamine increases activity of a fronto-striatal projection that regulates compulsive behavior

bioRxiv Preprint Server July 6, 2020 Gwynne L. Davis, Adelaide R. Minerva, Argentina Lario et al. preprint

Obsessive-Compulsive Disorder (OCD), characterized by intrusive thoughts (obsessions) and repetitive behaviors (compulsions), is associated with dysfunction in fronto-striatal circuits. There are currently no fastacting pharmacological treatments for OCD. However, recent clinical studies demonstrated that an intravenous infusion of ketamine rapidly reduces OCD symptoms. To probe mechanisms...