Ketamine and Esketamine in Obsessive-Compulsive Disorder: A Scoping Review of Clinical and Mechanistic Evidence.
Pharmaceuticals April 16, 2026 Maria Marmureanu, Mariana Valy Besoiu, Vlad Dionisie et al.
Background/Objective: A substantial proportion of patients with obsessive-compulsive disorder (OCD) does not respond adequately to first-line treatments such as selective serotonin reuptake inhibitors and cognitive-behavioral therapy. OCD has traditionally been conceptualized as a serotonergic disorder. However, emerging evidence suggests that glutamatergic dysfunction plays an important role....
DOI: 10.3390/ph19040628 (opens in new tab)
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Esketamine
OCD
Obsessive–compulsive disorder