Subanesthetic ketamine reactivates adult cortical plasticity to restore vision from amblyopia
bioRxiv Preprint Server March 16, 2020 Steven F. Grieco, Xin Qiao, Xiaoting Zheng et al. 14 citations preprint
Subanesthetic ketamine evokes rapid and long-lasting antidepressant effects in human patients. The mechanism for ketamine’s effects remains elusive, but ketamine may broadly modulate brain plasticity processes. We show that single-dose ketamine reactivates adult mouse visual cortical plasticity and promotes functional recovery of visual acuity defects from amblyopia. Ketamine specifically...