Lisa M Giocomo

Ketamine evoked disruption of entorhinal and hippocampal spatial maps

bioRxiv Preprint Server February 5, 2023 Francis Kei Masuda, Yanjun Sun, Emily A Aery Jones et al. 2 citations preprint

Ketamine, a rapid-acting anesthetic and acute antidepressant, carries undesirable spatial cognition side effects including out-of-body experiences and spatial memory impairments. The neural substrates that underlie these alterations in spatial cognition however, remain incompletely understood. Here, we used electrophysiology and calcium imaging to examine ketamine’s impacts on the medial...