Brain-penetrant microtubule-stabilizer epothilone B delays isoflurane-induced unconsciousness in mice.
Neuropharmacology April 1, 2026 Yixiang Huang, Zitong Qiu, Xinyue Yu et al. 2 citations
Inhalational anesthetics are currently believed to cause unconsciousness by acting on multiple molecular targets including neural ion channels, receptors, mitochondria, synaptic proteins, and cytoskeletal proteins. Inhalational anesthetics including isoflurane bind to cytoskeletal microtubules (MTs), potentially contributing to causing unconsciousness. This possibility is supported by our...