Microtubule-Stabilizer Epothilone B Delays Anesthetic-Induced Unconsciousness in Rats.
eNeuro August 1, 2024 Sana Khan, Yixiang Huang, Derin Timuçin et al. 23 citations
Volatile anesthetics are currently believed to cause unconsciousness by acting on one or more molecular targets including neural ion channels, receptors, mitochondria, synaptic proteins, and cytoskeletal proteins. Anesthetic gases including isoflurane bind to cytoskeletal microtubules (MTs) and dampen their quantum optical effects, potentially contributing to causing unconsciousness. This...