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Karl Looper

5 papers in the library · 47 citations · publishing 2016-2026

Papers

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The Music for Subanesthetic Infusions of Ketamine randomised clinical trial: ketamine as a psychedelic treatment for highly refractory depression

The British Journal of Psychiatry June 18, 2025 Kyle T. Greenway, Nicolas Garel, Lê-Anh Dinh-Williams et al. 8 citations

Background Ketamine exerts potent but transient antidepressant effects in treatment-resistant depression (TRD). Combinations of ketamine and psychotherapy have attracted interest, but no trial has investigated a psychedelic model of ketamine–psychotherapy for TRD to our knowledge. Aims This secondary analysis of a randomised clinical trial (RCT) explores the therapeutic effects and experiential...

The Montreal model: an integrative biomedical-psychedelic approach to ketamine for severe treatment-resistant depression

Frontiers in Psychiatry September 19, 2023 Nicolas Garel, Jessica Drury, Julien Thibault Lévesque et al. 32 citations

Background Subanesthetic ketamine has accumulated meta-analytic evidence for rapid antidepressant effects in treatment-resistant depression (TRD), resulting in both excitement and debate. Many unanswered questions surround ketamine’s mechanisms of action and its integration into real-world psychiatric care, resulting in diverse utilizations that variously resemble electroconvulsive therapy,...

Ketamine for depression: a potential role in requests for Medical Aid in Dying?

International Clinical Psychopharmacology September 1, 2023 Nicolas Garel, Michka Nazon, Kamran Naghi et al. 7 citations

Medical Aid in Dying (MAiD) is the act of a healthcare provider ending a patient's life, at their request, due to unbearable suffering from a grievous and incurable disease. Access to MAiD has expanded in the last decade and, more recently, it has been made available for psychiatric illnesses in a few countries. Recent studies have found that such psychiatric requests are rapidly increasing and...

Tolerability and suitability of brief group mindfulness-oriented interventions in psychiatric inpatients: a pilot study.

International journal of psychiatry in clinical practice September 1, 2016 Katerina Nikolitch, Vincent Laliberté, Ching Yu et al.

Mindfulness-oriented therapies have a positive impact on patients' overall well-being and alleviate many psychiatric conditions. However, little is known about their use in people with severe mental illness. We aimed to identify which clinical and sociodemographic factors are associated with suitability/tolerability of a brief group mindfulness-oriented therapy. This retrospective study...