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R Y Hampton

1 paper in the library · publishing 1982

Papers

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Stereospecific binding of 3H-phencyclidine in brain membranes.

Life Sciences June 21, 1982 R Y Hampton, F Medzihradsky, J H Woods et al.

Phencyclidine (PCP) displaceable binding of 3H-PCP to glass-fiber filters was eliminated and total binding markedly reduced by initial treatment of the discs with 0.05% polyethyleneimine. Assessed with treated filters, unlabeled PCP displaced 3H-PCP in both rat and pigeon brain membranes with an EC50 of 1 microM. Of similar high inhibitory potency were dextrorphan, levorphanol, SKF 10047 and...