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M Palmery

1 paper in the library · publishing 1995

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Interaction of beta-carbolines with central dopaminergic transmission in mice: structure-activity relationships.

Neuroscience Letters April 14, 1995 G Pimpinella, M Palmery

Although several beta-carboline alkaloids display hallucinogenic properties in humans, their mechanism of action remains unclear. To ascertain their influence on central dopaminergic transmission, in this study we investigated the facilitating effect of low doses of various beta-carbolines on L-DOPA (250 mg/kg)-induced stereotypy in mice. Harmaline (0.075, 0.15 and 0.35 mg/kg) and harmine...