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K Kaneko

1 paper in the library · publishing 1996

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The effects of single and repeated phencyclidine administration on [125I] iomazenil binding in the rat brain.

Neurochemistry International September 1996 K Kaneko, A Kuramaji, H Shibuya et al.

We measured [125I] iomazenil binding, labeling the central-type benzodiazepine receptor in 37 discrete rat brain areas following single (7.5 mg/kg, i.p.) and repeated (7.5 mg/kg/day x 14 days, i.p.) treatment with phencyclidine (PCP), a non-competitive antagonist of the N-methyl-D-aspartate(NMDA)-type glutamate receptor, using in vitro quantitative autoradiographic receptor binding assay. Both...