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Tosihide Kuroki

1 paper in the library · publishing 2011

Papers

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Positive association of phencyclidine-responsive genes, PDE4A and PLAT, with schizophrenia.

American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics December 2011 Xiangdong Deng, Hiromi Takaki, Lixiang Wang et al.

As schizophrenia-like symptoms are produced by administration of phencyclidine (PCP), a noncompetitive antagonist of N-methyl-D-aspartate (NMDA) receptors, PCP-responsive genes could be involved in the pathophysiology of schizophrenia. We injected PCP to Wistar rats and isolated five different parts of the brain in 1 and 4 hr after the injection. We analyzed the gene expression induced by the...