Effect of Esketamine Pretreatment on Necroptosis in Mice with Trigeminal Neuralgia and Anxiety-Like Behavior via the RIP1/RIP3/MLKL Pathway.
Cellular and molecular neurobiology July 28, 2026 Rui Dong, Yuan Tian, Chendi Zhao et al.
To explore the effect of esketamine (ES) pretreatment on necroptosis in mice with trigeminal neuralgia accompanied by anxiety-like behavior and its correlation with the RIP1/RIP3/MLKL signaling pathway. Thirty male C57BL/6J mice were randomized into five groups (n=6): Control, Sham, model group (PIONT), PIONT+NS, and PIONT+ES. Trigeminal neuralgia model was established by left infraorbital...
DOI: 10.1007/s10571-026-01782-y (opens in new tab)
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Anxiety-like behavior
Esketamine pretreatment
Necroptosis
Rip1/rip3/mlkl pathway
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