Ketamine exerts rapid antidepressant effects but is limited by dissociative and abuse-related side effects, highlighting the need for safer alternatives. Here, we identify 3C-DCK, a rationally designed ketamine derivative, through adenosine dynamics in the medial prefrontal cortex (mPFC). Using the GRABAdo1.0 sensor, we show that 3C-DCK elicits more potent and sustained extracellular adenosine...
Objective: To evaluate the effect of mindfulness training in addition to essential psychological counseling on the clinical pregnancy rate in women undergoing frozen embryo transfer (FET), and to explore the potential mediating role of neuropsychological improvements. Methods and analysis: This study will be conducted as a single-center, parallel-group, open-label, exploratory randomized...