Recent debates about AI "guardrails" in mental health have framed a problem as one of detecting delusion. This paper argues that such framing misunderstands both psychiatry and large language models. In clinical practice, delusion is not simply a false belief but a structure of conviction that stabilizes meaning under conditions of uncertainty. Large language models, by contrast, generate...
Treatment-resistant mood disorders are often managed with intensive interventions that include electroconvulsive therapy (ECT), transcranial magnetic stimulation (TMS), ketamine, and esketamine, but the role of genetics in clinical response to those interventions is yet to be clearly determined. Here, we review the current literature on the genetics of response to these treatment modalities. To...