544. MOLECULAR AND CELLULAR MECHANISMS OF THE LONG-LASTING EFFECTS OF PSYCHEDELICS AND THEIR NON-HALLUCINOGENIC DERIVATIVES
The International Journal of Neuropsychopharmacology August 1, 2025 Argel Aguilar-Valles, Dhiral Kot, Vern Lewis et al.
Abstract Background Major depressive disorder (MDD) is a multifactorial and heterogeneous disorder that affects around 280 million individuals worldwide, with approximately 80 million experiencing treatment-resistant depression (TRD). Neuronal hypotrophy and axon hypomyelination in the prefrontal cortex (PFC) are hallmark features of MDD, highlighting the need for treatments that address these...