Charlie J Maddox

Increased encoding of aversive stimuli by lateral habenula neurons during Δ9-tetrahydrocannabinol withdrawal.

Nature Communications September 3, 2026 Eun-Kyung Hwang, Deborah Daphne, Charlie J Maddox et al.

The lateral habenula (LHb) integrates cortical and basal forebrain (BF) input and is implicated in negative affective states, but its involvement in negative affect associated with cannabis withdrawal is unknown. Here, effects of withdrawal from the psychoactive cannabis constituent, Δ9-tetrahydrocannabinol (Δ9-THC), on fear conditioning (FC) and LHb function were measured in rats using calcium...