Cytochrome P450 Inhibition by Psilocybin and Psilocin: A Combined Molecular Dynamics and Enzymatic Screening Study
RevSALUS - Revista Científica da Rede Académica das Ciências da Saúde da Lusofonia May 1, 2026 Andreia Machado Brito-Da-Costa, Mariana Carvalho, Ricardo Jorge Dinis-Oliveira et al.
Psilocybin is a hallucinogen produced by “magic mushrooms”, being rapidly metabolized in the organism into psilocin (Brito-da-Costa et al., 2022; Dinis-Oliveira, 2017). A scientific gap exists regarding the possible interactions between psilocybin/psilocin and CYP450 enzymes. Given their biological importance and since the binding of drugs to CYP450 enzymes can interfere with the metabolism of...