Electrophysiologic changes in ventral midbrain dopaminergic neurons resulting from (+/-) -3,4-methylenedioxymethamphetamine (MDMA-"Ecstasy").
Biological Psychiatry September 15, 2007 Mauro Federici, Luca Sebastianelli, Silvia Natoli et al.
Although dopamine (DA) has been implicated in the psychostimulant properties of 3,4-methylenedioxymethamphetamine (MDMA), there is no detailed information on its modalities of action on single ventral midbrain dopaminergic neurons. We examined the actions of MDMA on intracellularly recorded dopaminergic neurons maintained in slices. At 1 micromol/L, MDMA depolarized and excited the cells; at 3...