Synthesis and biological evaluation of 18-methoxycoronaridine congeners. Potential antiaddiction agents.
Journal of Medicinal Chemistry June 1, 2003 Martin E. Kuehne, Liwen He, Patrick A Jokiel et al.
Variation of the methoxycarbonyl and C-18 substituents of the antiaddictive compound 18-methoxycoronaridine, and contraction of its isoquinuclidine ring segment, provided 15 congeners for SAR evaluation at opioid and alpha3beta4 nicotinic acetylcholine receptors. The opioid activities were relatively low, and the alpha3beta4 nicotinic acetylcholine receptor activities were found to correlate...
DOI: 10.1021/jm020562o (opens in new tab)
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Ibogaine
Cell line
Animals
Humans
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