Dopamine transporter down-regulation following repeated cocaine: implications for 3,4-methylenedioxymethamphetamine-induced acute effects and long-term neurotoxicity in mice.
British Journal of Pharmacology December 10, 2009 Inés Peraile, Elisa Torres, Andrea Mayado et al.
Background and purpose: 3,4-Methylenedioxymethamphetamine (MDMA) and cocaine are two widely abused psychostimulant drugs targeting the dopamine transporter (DAT). DAT availability regulates dopamine neurotransmission and uptake of MDMA-derived neurotoxic metabolites. We aimed to determine the effect of cocaine pre-exposure on the acute and long-term effects of MDMA in mice. Experimental...
DOI: 10.1111/j.1476-5381.2009.00522.x (opens in new tab)
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Corpus striatum
Cell membrane
Animals
Mice
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