Ross D Hoehn

Neuroreceptor activation by vibration-assisted tunneling.

Scientific Reports April 24, 2015 Ross D Hoehn, David Nichols, Hartmut Neven et al.

G protein-coupled receptors (GPCRs) constitute a large family of receptor proteins that sense molecular signals on the exterior of a cell and activate signal transduction pathways within the cell. Modeling how an agonist activates such a receptor is fundamental for an understanding of a wide variety of physiological processes and it is of tremendous value for pharmacology and drug design....