Ketamine's rapid and sustained antidepressant effects are driven by distinct mechanisms.
Cellular and molecular life sciences : CMLS February 27, 2024 Radhika Rawat, Elif Tunc-Ozcan, Sara Dunlop et al. 17 citations
Administration of multiple subanesthetic doses of ketamine increases the duration of antidepressant effects relative to a single ketamine dose, but the mechanisms mediating this sustained effect are unclear. Here, we demonstrate that ketamine's rapid and sustained effects on affective behavior are mediated by separate and temporally distinct mechanisms. The rapid effects of a single dose of...