Increased posterior default mode network activity and structural connectivity in young adult APOE -ε4 carriers: a multi-modal imaging investigation
bioRxiv March 22, 2018 Carl J. Hodgetts, Jonathan P. Shine, Huw Williams et al. preprint
Young adult APOE -ε4 carriers show increased activity in posterior regions of the default mode network (pDMN), but how this is related to structural connectivity is unknown. Thirty young adults (half APOE -ε4 carriers, the other half APOE -ε3ε3/ε2ε3; mean age 20 years) were scanned using both diffusion and functional magnetic resonance imaging. Diffusion tractography was used to quantify the...