Background: Shame is a component that contributes to psychopathology yet few interventions target it directly. Psychedelic-assisted therapy has been investigated as an intervention targeting shame and its associated burden. As part of psychedelic efficacy is mediated by expectation effects the true effect a psychedelic intervention may provide is unknown. Here we examined whether a psychedelic...
The intensity of altered states of consciousness (ASC) induced by a psychedelic represents a key mechanism underlying the therapeutic effects of psychedelic-assisted therapy (PAT). However, growing evidence suggests that expectations may contribute significantly to therapeutic effects of PAT. The present study examined whether a psychedelic placebo could induce an ASC in a PAT- analogous...
Ketamine and esketamine offer a novel approach in the pharmacological treatment of major depressive disorder (MDD). This meta-analysis aimed to investigate the placebo response in double-blind, randomized controlled studies (RCTs) on patients with MDD receiving ketamine or esketamine. For this systematic review and meta-analysis Medline (PubMed), Cochrane Central Register of Controlled Trials...