Time-dependent antidepressant-like effects of reelin and ketamine in the repeated-corticosterone model of chronic stress.
Progress in Neuro-Psychopharmacology and Biological Psychiatry June 8, 2024 Kaylene K A Scheil, Carla L Sánchez-Lafuente, Brady S Reive et al. 5 citations
There is an urgent need for novel antidepressants, given that approximately 30% of those diagnosed with depression do not respond adequately to first-line treatment. Additionally, monoaminergic-based antidepressants have a substantial therapeutic time-lag, often taking months to reach full therapeutic effect. Ketamine, an N-methyl-d-aspartate receptor (NMDAR) antagonist is the only current...
DOI: 10.1016/j.pnpbp.2024.110998 (opens in new tab)
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Ketamine
Chronic stress
Corticosterone
Rapid-acting antidepressants
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