Kaylene K A Scheil

2 papers in the library · 5 citations · publishing 2023-2024

Papers

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Time-dependent antidepressant-like effects of reelin and ketamine in the repeated-corticosterone model of chronic stress.

Progress in Neuro-Psychopharmacology and Biological Psychiatry June 8, 2024 Kaylene K A Scheil, Carla L Sánchez-Lafuente, Brady S Reive et al. 5 citations

There is an urgent need for novel antidepressants, given that approximately 30% of those diagnosed with depression do not respond adequately to first-line treatment. Additionally, monoaminergic-based antidepressants have a substantial therapeutic time-lag, often taking months to reach full therapeutic effect. Ketamine, an N-methyl-d-aspartate receptor (NMDAR) antagonist is the only current...

DOI: 10.1016/j.pnpbp.2024.110998 Full text Ketamine Chronic stress Corticosterone Rapid-acting antidepressants +5

Reelin Rescues Behavioral, Electrophysiological, and Molecular Metrics of a Chronic Stress Phenotype in a Similar Manner to Ketamine.

eNeuro August 2023 Jenessa N Johnston, Josh Allen, Irene Shkolnikov et al.

Over the past decade, ketamine, an NMDA receptor antagonist, has demonstrated fast-acting antidepressant effects previously unseen with monoaminergic-based therapeutics. Concerns regarding psychotomimetic effects limit the use of ketamine for certain patient populations. Reelin, an extracellular matrix glycoprotein, has shown promise as a putative fast-acting antidepressant in a model of...

DOI: 10.1523/eneuro.0106-23.2023 Full text Depression Ketamine Synaptic plasticity Corticosterone +2