Hiroo Ishida

A clinical pharmacokinetic microdosing study of docetaxel with Japanese patients with cancer.

Cancer chemotherapy and pharmacology October 2015 Ken-ichi Fujita, Etsuko Yoshino, Kaori Kawara et al.

Whether microdosing studies can be used to evaluate the human pharmacokinetics of new anticancer drugs remains unclear. The disposition of docetaxel in cancer patients is linear in terms of dose proportionality. We examined whether the pharmacokinetics of docetaxel in a clinically relevant therapeutic dose could be predicted from the pharmacokinetics of a microdose of docetaxel in Japanese...