Effects of the phencyclidine model of schizophrenia and nicotine on total and categorized ultrasonic vocalizations in rats
Behavioural Pharmacology June 1, 2016 Natashia Swalve, Michele M. Mulholland, Tiffany D. Schulz et al.
Patients with schizophrenia smoke cigarettes at a higher rate than the general population. We hypothesized that a factor in this comorbidity is sensitivity to the reinforcing and reinforcement-enhancement effects of nicotine. Phencyclidine (PCP) was used to model behavioral changes resembling negative symptoms of schizophrenia in rats. Ultrasonic vocalizations (USVs) in rats have been used to...