Susceptibility of the adolescent brain to cannabinoids: long-term hippocampal effects and relevance to schizophrenia
Translational Psychiatry November 27, 2012 Kelly A. Gleason, Shari G. Birnbaum, Abhay Anand Shukla et al. 79 citations
Clinical studies report associations between cannabis use during adolescence and later onset of schizophrenia. We examined the causal relationship between developmental cannabinoid administration and long-term behavioral and molecular alterations in mice. Mice were administered either WIN 55,212-2 (WIN), a cannabinoid receptor 1 (CB1) agonist or vehicle (Veh) during adolescence (postnatal day...