Δ9-Tetrahydrocannabinol changes the brain lipidome and transcriptome differentially in the adolescent and the adult.
Biochimica et biophysica acta. Molecular and cell biology of lipids May 2018 Emma Leishman, Michelle Murphy, Ken Mackie et al.
Exposing the adolescent brain to drugs of abuse is associated with increased risk for adult onset psychopathologies. Cannabis use peaks during adolescence, with largely unknown effects on the developing brain. Cannabis' major psychoactive component, Δ9-tetrahydrocannabinol (THC) alters neuronal, astrocytic, and microglial signaling. Therefore, multiple cellular and signaling pathways are...
DOI: 10.1016/j.bbalip.2018.02.001 (opens in new tab)
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THC
Adolescent brain
Endocannabinoid
Lipidomics
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