Collybolide is a novel biased agonist of κ-opioid receptors with potent antipruritic activity.
Proceedings of the National Academy of Sciences May 24, 2016 Achla Gupta, Ivone Gomes, Erin N Bobeck et al.
Among the opioid receptors, the κ-opioid receptor (κOR) has been gaining considerable attention as a potential therapeutic target for the treatment of complex CNS disorders including depression, visceral pain, and cocaine addiction. With an interest in discovering novel ligands targeting κOR, we searched natural products for unusual scaffolds and identified collybolide (Colly), a nonnitrogenous...
DOI: 10.1073/pnas.1521825113 (opens in new tab)
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Salvinorin a
G-protein–coupled receptors
Antinociception
Dynorphin
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