Kristofer J Schoepfer

Sex- and dose-dependent abuse liability of repeated subanesthetic ketamine in rats.

Physiology & Behavior May 1, 2019 Kristofer J Schoepfer, Caroline E. Strong, Samantha K Saland et al.

Subanesthetic ketamine (KET) elicits rapid, robust, but transient antidepressant effects. KET's antidepressant actions can be augmented and maintained for a longer duration when repeatedly delivered. However, KET is recreationally abused, raising long-term treatment safety concerns. Women are more likely than men to seek treatment for depression, escalate from casual to compulsive drug use, and...