Applying ketamine to alleviate the PTSD-like effects by regulating the HCN1-related BDNF.
Progress in Neuro-Psychopharmacology and Biological Psychiatry August 30, 2018 Lanwei Hou, Yirui Qi, Hongwei Sun et al.
Post-traumatic stress disorder (PTSD) is commonly associated with concurrent anxiety and depression symptoms, and reduce the expression of the Brain-Derived Neurotrophic Factor (BDNF) which promotes the proliferation and survival of neurons. The hyperpolarization-activated cyclic nucleotide-gated channel 1(HCN1) could be inhibited by the ketamine, a drug to alleviate depression and anxiety, and...
DOI: 10.1016/j.pnpbp.2018.03.019 (opens in new tab)
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Ketamine
Post-traumatic stress disorder
Brain-derived neurotrophic factor
Prefrontal cortex