A Review of the Mechanism of Antagonism of N-methyl-D-aspartate Receptor by Ketamine in Treatment-resistant Depression.
Cureus May 18, 2018 Yasar Sattar, John M Wilson, Ali M Khan et al.
The biochemical processes involved in depression go beyond serotonin, norepinephrine, and dopamine. The N-methyl-D-aspartate (NMDA) receptor has a major role in the neurophysiology of depression. Ketamine, one of the prototypical NMDA antagonists, works rapidly in controlling depressive symptoms, including acutely suicidal behavior, by just a single injection. Ketamine may rapidly increase the...
DOI: 10.7759/cureus.2652 (opens in new tab)
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Depression
Ketamine
Nmda antagonist
Nmda receptor
+1