European PsychiatryApril 1, 2021Mahwish Adnan, F. Motiwala, Zeeshan Mansuri et al.
Introduction The immediate antidepressant effect of Ketamine has become a breakthrough in the treatment of depression. Cytochrome CYP3A4 and 2B6 primarily metabolize Ketamine. Objectives The present study explores potential pharmacokinetic and pharmacodynamic interactions of Lamotrigine and Ketamine. Methods A literature search was conducted using (“ketamine” OR “Lamotrigine” AND Interactions...
The biochemical processes involved in depression go beyond serotonin, norepinephrine, and dopamine. The N-methyl-D-aspartate (NMDA) receptor has a major role in the neurophysiology of depression. Ketamine, one of the prototypical NMDA antagonists, works rapidly in controlling depressive symptoms, including acutely suicidal behavior, by just a single injection. Ketamine may rapidly increase the...